Biology 221-03: Genetics

Spring 2015

Dr. Wade Worthen, TNS 171B
wade.worthen@furman.edu
Phone: 294-3390
Office Hrs: by appt

Lecture: 10:00-11:15 T, TH, Plyler 143 (Biology Seminar Room)
Lab: 2:30-5:20, W, TNS 172
Text: Essentials of Genetics, 8th ed., Klug, Cummings, and Spencer.

COURSE OVERVIEW



Welcome to Genetics! More than any other subdiscipline, genetics is truly fundamental to all of biology. At a biochemical level, genes are the recipes for the proteins made by the cell, which will determine a cell's structure and function. A major part of cell division is dividing the DNA correctly into two daughter cells, which in turn will divide to produce a multicellular organism. Sexual reproduction, at a cellular level, is the joining of two sets of genes, making a new genetic recipe. At the organismal level, changes in gene regulation cause differences in cell, tissue, and organ function, and cause changes in development through an organism's lifetime. Finally, changes in genetic structure are how populations evolve. So, from the cellular level to the organismal level to the populational level, genetics is fundamental to all of biology. We will examine each of these levels in detail through this course. So, whether you are interested in molecular biology, physiology, or ecology and evolution, this course should be relevant and interesting to you.

LECTURE SYLLABUS

DATE TOPIC (and study questions) PPT AUDIO READINGS
LAB
JAN 13 (T)
JAN 15 (TH)
Darwin, Mendel, and Modern Biology
The Cellular Context
ppt
ppt
audio ppt
audio ppt
1, 3
2
safety video, Drosophila
JAN 20 (T)
JAN 22 (TH)
Modification to Mendelian Patterns I
Modifications to Mendelian Patterns II QUIZ #1
ppt
ppt
audio ppt
audio ppt
4
4
Mendel's Peas
JAN 27 (T)
JAN 29 (TH)
Sex Determination and Sex Linkage
Linkage and Mapping
ppt
ppt
audio ppt
audio ppt
5
7
F1 Data and Back Cross
FEB 3 (T)
FEB 5 (TH)
Bacterial Genetics and Mapping
DNA Structure
ppt
ppt
audio ppt
audio ppt
8
9
EXAM #1
FEB 10 (T)
FEB 12 (TH)
Chromosome Structure
DNA Replication
ppt
ppt
audio ppt
audio ppt
11
10
F2 Data

FEB 17 (T)
FEB 19 (TH)
DNA Replication II
Transcription
ppt
ppt
audio ppt
audio ppt
10
12
Bacteria, Fingerprinting QUIZ #2
FEB 24 (T)
FEB 26 (TH)
Translation
Regulation of Gene Expression
ppt
ppt
audio ppt
audio ppt
13
13
MOVIE: The Double Helix
MAR 3 (T)
MAR 5 (TH)
REVIEW
Mutation I
.
ppt
.
audio ppt
.
6
EXAM #2
MAR 10 (T)
MAR 12 (TH)
SPRING BREAK      
MAR 17 (T)
MAR 19 (TH)
Mutation II
NO CLASS - INAUGURATION OF PRESIDENT DAVIS
ppt
.
audio ppt
.
16
.
p53 Gel Electrophoresis
MAR 24 (T)
MAR 26 (TH)
Cancer Genetics
Recombinant DNA Technology I
ppt
ppt
audio ppt
audio ppt
17
18
ptc PCR, QUIZ #3
MAR 31 (T)
APR 2 (TH)
Genomics
Recombinant Technology II
ppt
ppt
audio ppt
audio ppt
19
20
Restriction Digest, Bioinformatics
APR 7 (T)
APR 9 (TH)
Developmental Genetics
Quantitative and Behavior Genetics
ppt
ppt
audio ppt
audio ppt
21
22
EXAM #3
APR 14 (T)
APR 16 (TH)
FURMAN ENGAGED!!
Population Genetics I
.
ppt
.
audio ppt
.
22
Population Genetics Modeling
APR 21 (T)
APR 23 (TH)
Population Genetics II
Evolutionary Genetics
ppt
ppt
audio ppt
audio ppt
22
22
Population Genetics Game
APR 28 (T)
MAY 5 (T)
Finish Evolutionary Genetics, QUIZ #4
FINAL EXAM: 8:30-11:00
.
.
.
.
23
.

ATTENDANCE AND GRADING POLICY

The university's policy, which I will employ in BIO221, is as follows:
"Instructors are expected to establish and announce attendance requirements for their courses. Unless an instructor announces otherwise, the following guidelines are assumed to be in effect: Freshman will be withdrawn from a course if absent, for any reason, 15 percent of the class meetings (No more than 5 for this class). Other students will be withrawn from a course if absent 25 percent of the class meetings (no more than 7 for this class). In both cases, a failing grade (F) will be recorded unless the absences were due to providential reasons, in which case a grade of W may be assigned after consultation with the Associate Academic Dean" (University Catalog).

Attendance at lab is mandatory; you cannot take another section's lab unless prior arrangements are made, and only in the most unusual circumstances.
If you have a disability and you need academic accomodations, you should contact the Office of Disability Services. Do this in a timely manner, early in the term. Then, you should bring this request to me.


Grading Policy:
I will assign grades in the following manner. There are 700 available points, and letter grades will be assigned such that grades of 90% or above earn at least an "A range" grade, 80%-89% at least a "B range" grade, and so forth. Determination of these letter grade cutoffs will be at the sole discretion of the professor; "curving", if warranted, will be on total points accumulated and not individual assignments. +/- grades will be assigned based on total percentage of points earned, with some subjective modification possible if there is signifiacnt improvement on the final exam.


ASSIGNMENT POINTS
Lecture Exams, 3@ 100 each 300
Lecture Quizzes 4 @ 25 100
Lab Exercises 150
Final Exam (comprehensive) 150
TOTAL 700