Welcome to Chosed Lab
My primary research goal is to understand the role that posttranslational modifications play in disease progression. Posttranslational modifications function to regulate a variety of events in the cell including protein targeting, degradation, enzymatic activity and protein-protein interactions.
I am highly interested in learning how the enzymes that add and remove posttranslational modifications from target proteins are involved in various neurodegenerative diseases. My past research has focused on the regulated removal of one posttranslational modification, SUMO, by an enzyme from a plant pathogen. I have also studied how protein methylation impacts the enzymatic activity of a large protein complex involved in transcriptional regulation. By examining the different aspects of regulation of posttranslational modifications, I have developed an interest in how the modifying enzymes play a role disease progression.
My lab uses the yeast Saccharomyces cerevisiae as a model system as well as in vitro systems.
About Renee Chosed
As an elementary school student, I participated in my first science fair by examining the growth of plants treated with different fertilizers. Unsurprisingly, it didn’t turn out to be the most daunting experiment of my professional career. I loved the process of developing a hypothesis and then performing experiments to test my ideas even if it was just measuring plant height. But from that basic experience, I gained something invaluable — a passion for science.
Two decades later, that infatuation has blossomed into a scientific career as an educator and researcher. One of the most fulfilling aspects of my career is that I have an opportunity to inspire the next generation of scientists. As a teacher, it’s my responsibility to encourage these students to ask questions, pursue answers and generate solutions. It’s a task that I don’t take lightly because science is about dedication. Great discoveries aren’t made overnight. Most, in fact, are the result of life-long pursuits. So to prepare students for that demanding world, I strive to provide them with a basic and firm foundation that will enable them to pursue their research interests. Along the way, I hope to instill a passion in them through my own enthusiasm and fascination.
I earned a B.S. in Biochemistry and Molecular Biology from Trinity University in 2001. During my undergraduate years I researched in the biochemistry lab of Dr. William Kurtin at Trinity University and for a summer in the SMART Program at Baylor College of Medicine in a cancer research lab.
Upon graduation from Trinity, I attend graduate school at the University of Texas Southwestern Medical Center in Dallas where I was a research student in the lab of Dr. Kim Orth in the Dept. of Molecular Biology. I earned my Ph.D. in Biological Chemistry in 2006. I then moved to Houston, TX and was an Odyssey Postdoctoral Fellow in the lab of Dr. Sharon Dent in the Dept. of Biochemistry and Molecular Biology at UT MD Anderson Cancer Center.
My first teaching experience came as a Visiting Assistant Professor in the Dept. of Biology at Trinity University from 2009-2011.